The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARαActivation
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چکیده
منابع مشابه
Oleanolic Acid Enhances the Beneficial Effects of Preconditioning on PC12 Cells
Preconditioning triggers endogenous protection against subsequent exposure to higher concentrations of a neurotoxin. In this study, we investigated whether exposure to oleanolic acid (OA) enhances the protective effects of preconditioning on PC12 cells exposed to 6-hydroxydopamine (6-OHDA). A concentration response curve was constructed using 6-OHDA (50, 150, 300, and 600 μM). The experiment co...
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CRYSTALS OF THE TITLE COMPOUND (SYSTEMATIC NAME: 3β-hy-droxy-olean-12-en-28-oic acid ethanol monosolvate), C(30)H(48)O(3)·C(2)H(5)OH, were obtained from unsuccessful co-crystallization trials. The asymmetric unit contains two symmetry-independent oleanolic acid mol-ecules, as well as two ethanol solvent mol-ecules. Inter-molecular O-H⋯O hydrogen bonds stabilize the crystal packing. In the olean...
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The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and OA on platelet aggregation was examined on...
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Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2018
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2018/3180396